Arrhythmias & electrophysiology

Pulsed field ablation with a pentaspline catheter for ventricular arrhythmias: First US series

Heart RhythmPublished Case series

Authors' conclusion

In this first US series, VT/PVC ablation using a pentaspline PFA catheter for large VT substrate modification or after acute RFA failure appeared effective and safe, with promising acute and mid-term follow-up results.

Study context

Population
Consecutive patients undergoing pentaspline pulsed field ablation (PFA) for ventricular tachycardia (VT) or premature ventricular contractions (PVCs), May–October 2024 (VT substrate ablation in large scars or bailout after acute radiofrequency failure)9 VT, 2 PVC
Participants
11 patients
Outcome
Safety and efficacy of pentaspline PFA for ventricular arrhythmias
Methodological detailsconsecutive patients
  • Consecutive patients

Main finding

As reported in the abstract

Bailout after acute radiofrequency ablation (RFA) failure: targeted VT/PVC suppressed in all cases

4

Large VT substrate modification or PVC: PFA only

2

Large VT substrate modification or PVC: touch-up RFA to complete substrate modification

5

Observational data: associations, not effects.

Further findings

Recurrence · mean follow-up 6 months

VT recurrence (patients)
2
PVC recurrence (patients)
1

Safety

Procedure-related complications

No procedural-related complications

Original publication

Pulsed field ablation with a pentaspline catheter for ventricular arrhythmias: First US series. Heart Rhythm. Published 13 June 2025. doi:10.1016/j.hrthm.2025.06.006

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