Acute cardiac care & resuscitation
Effect of adjuvant thiamine and ascorbic acid administration on the neurologic outcomes of out-of-hospital cardiac arrest patients: A before-and-after study
Authors' conclusion
Adjuvant thiamine and ascorbic acid administration in OHCA survivors with TTM did not improve their neurologic outcome after one month.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management
- Participants
- 234 survivors
- Exposure
- Thiamine + ascorbic acid vs no vitamin supplementation
- Treatmentn = 102
- Controln = 132reference
- Outcome
- Good neurologic outcome (Cerebral Performance Category score ≤ 2)
- Follow-up
- 1 month
Methodological details2 hospitals, Korean Hypothermia Network prospective registry, inverse probability of treatment weighting (IPTW)-adjusted
- 2 hospitals, Korean Hypothermia Network prospective registry
- IPTW-adjusted
Main finding
As reported in the abstract
Good neurologic outcome (CPC ≤ 2)
P = 0.76
- Vitamin supplementation, IPTW-adjusted OR for good neurologic outcome (95% CI 0.644-1.999; P = 0.66); not associated
- 1.134
Observational data: associations, not effects.
Further findings
Good neurologic outcome, older (≥65 years) subgroup · 1 month
- Vitamin administration, adjusted OR for good neurologic outcome in older (≥65 years) patients (95% CI 1.21-25.23; P = 0.03); significantly associated
- 5.53
Original publication
Effect of adjuvant thiamine and ascorbic acid administration on the neurologic outcomes of out-of-hospital cardiac arrest patients: A before-and-after study. Resuscitation. Published 27 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it