Acute cardiac care & resuscitation
Time-course relationship between cerebrospinal fluid and serum concentrations of midazolam and albumin in patients with cardiac arrest undergoing targeted temperature management
Authors' conclusion
In CSF, midazolam and albumin concentrations peaked 24 h post-cardiac arrest. Midazolam and albumin C/S ratios were significantly higher in the poor outcome group and positively correlated with each other, suggesting blood-brain barrier disruption 24 h post-cardiac arrest.
Study context
- Population
- Patients with cardiac arrest undergoing targeted temperature management, May 2020–April 2022
- Participants
- 19 patients
- Exposure
- Good vs poor neurologic outcome
- Poorn = 13
- Outcome
- Time-course of CSF and serum midazolam and albumin concentrations and CSF/serum ratios
- Follow-up
- 0, 24, 48 and 72 h after return of spontaneous circulation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Serum midazolam lowest and serum albumin highest at 0 h; Cerebrospinal fluid (CSF) concentrations of both peaked at 24 h
- No significant inter-group differences in midazolam concentrations in CSF or serum
- C/S ratios of midazolam and albumin significantly differed between groups
- Moderate to strong positive correlations between midazolam and albumin C/S ratios
Observational data: associations, not effects.
Original publication
Time-course relationship between cerebrospinal fluid and serum concentrations of midazolam and albumin in patients with cardiac arrest undergoing targeted temperature management. Resuscitation. Published 9 June 2023. doi:10.
Summarised from the published abstract; every number is checked against it