Heart failure & cardiomyopathies
Effect of a Meal on Invasive Hemodynamics and Plasma Incretin Levels in Patients With Heart Failure
Authors' conclusion
Patients with heart failure showed a blunted cardiac index response to meal intake, elevated total GLP-1 levels that were associated with hemodynamic parameters, and increased gastrointestinal symptom burden.
Study context
- Population
- Patients with chronic heart failure and healthy controls
- Participants
- 14 vs 10
- Comparison
- Patients, compared with controls
- Patientsn = 14
- Controlsn = 10
- Outcome
- Postprandial peak in cardiac index
Main finding
As reported in the abstract
P < 0.001
Further findings
Fasting total GLP-1 levels · higher in patients
P = 0.015
Postprandial peak total GLP-1 · greater in patients
P = 0.013
- Cardiac index response in the postprandial period (baseline-substracted area under the curve) · blunted in patients
- P = 0.030
- Gastrointestinal symptom burden · higher in patients
- P = 0.033
Correlation of fasting total GLP-1 with central venous pressure
- Fasting total GLP-1 concentrations correlated with central venous pressure
- P = 0.025
Correlation of area under the curve total GLP-1 with cardiac index
- Trend toward a correlation
- P = 0.054
GIP concentrations
- No change in GIP concentrations
Correlation of indigestion score with peak superior mesenteric artery blood flow
- Indigestion score correlated with peak superior mesenteric artery blood flow
- P = 0.017
Original publication
Effect of a Meal on Invasive Hemodynamics and Plasma Incretin Levels in Patients With Heart Failure. Circ Heart Fail. Published 7 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →