Effect of active vitamin-D on left ventricular mass index: Results of a randomized controlled trial in type 2 diabetes and chronic kidney disease
Authors' conclusion
The study did not provide evidence that treatment with calcitriol as compared to placebo might improve LVMI in patients with T2D, mild left ventricular hypertrophy and stable CKD.
Study context
- Population
- Patients with T2DM, chronic kidney disease (CKD) stage 3 and raised LV mass on stable renin angiotensin aldosterone system blockade, with elevated intact parathyroid hormonemale 73%
- Participants
- 45 patients
- Comparison
- Calcitriol vs placebo
- Calcitrioln = 19
- Placebon = 26reference
- Primary endpoint
- Change from baseline in LV mass index (left ventricular mass index (LVMI)) by MRI
- Follow-up
- 48 weeks
Methodological detailssingle-centre, double-blind, parallel group, placebo-controlled
- Single-centre
- Double-blind
- Parallel group
- Placebo-controlled
Primary result
LVMI
Median difference
1.84
95% CI −1.28 to 4.96
Between Calcitriol and Placebo
median difference 1.84 (95% CI −1.28 to 4.96)
As reported in the abstract
Secondary outcomes
- Intact parathyroid hormone (Calcitriol, baseline to 48 weeks)
- 76 · median · IQR 41–204 · pg/mL
- Intact parathyroid hormone (Calcitriol, baseline to 48 weeks) — Fell only in the calcitriol group
- P= .04
Interstitial myocardial fibrosis and other secondary endpoints
- No significant differences
Original publication
Effect of active vitamin-D on left ventricular mass index: Results of a randomized controlled trial in type 2 diabetes and chronic kidney disease. Am Heart J. Published 17 March 2023. doi:10.
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