Acute cardiac care & resuscitation
Effect of immunomodulation on post-cardiac arrest brain injury: a systematic review and meta-analysis
Pooled result · Favorable neurological outcomeResult — go to the resultRelative risk 1.04 95% CI 0.85–1.28Authors' conclusion
Across all studies, immunomodulating therapies were not associated with significant increases in favorable neurologic outcomes or survival. Between-study heterogeneity in intervention dosage, outcomes, timing of assessment, and biomarker profiling limited direct comparison and supports the need for future trials. Prospero registration: CRD420251068980.
Study context
- Population
- Adults resuscitated following in- and out-of-hospital cardiac arrest11 studies plus 3 sub-studies
- Participants
- 2,605 adults
- Comparison
- Immunomodulatory therapeutics in patients resuscitated following cardiac arrest
- Outcome
- Favorable neurological outcome
Methodological detailsrandomized controlled trials, random effect model, Cochrane Risk of Bias 2 tool, GRADE methodology
- Randomized controlled trials
- Random effect model
- Cochrane Risk of Bias 2 tool
- GRADE methodology
Pooled result
As reported in the abstract
Relative risk
1.04
95% CI 0.85–1.28
Immunomodulatory therapies
RR 1.04 (95% CI 0.85–1.28)
Further pooled results
Mortality
| RR (95% CI) | ||
|---|---|---|
| Immunomodulatory therapiesNot associated with a decrease | 0.97 (0.91–1.03) | |
| 0.512Relative risk (log scale) |
IL-6 levels · 24 h following glucocorticoid administration
- A trend toward decreased IL-6 levels
Search and study selection
- Studies yielded
- 19,558
- Duplicates
- 2351
- Full texts reviewed
- Fifty-eight
- The overall quality of evidence was limited by heterogeneous interventions and timing.
Original publication
Effect of immunomodulation on post-cardiac arrest brain injury: a systematic review and meta-analysis. Resuscitation. Published 11 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →