Pulmonary vascular disease & thromboembolism
Effect of Pharmacomechanical Catheter-Directed Thrombolysis on Segmental Artery Occlusions: Insights From the RESCUE Trial
Authors' conclusion
PM-CDT with the Bashir catheter was associated with a significant reduction in total and subtotal occlusion of segmental and proximal PAs.
Study context
- Population
- Acute intermediate-risk pulmonary embolism (PE) with RV dilatation treated with pharmacomechanical catheter-directed thrombolysis (PM-CDT) (Bashir endovascular catheter)
- Participants
- 107 participants18 US sites
- Comparison
- 48 h after PM-CDT vs baseline
- Primary endpoint
- Change in number of segmental and proximal PA branches with total or subtotal (>65%) occlusions (McNemar's test)
- Follow-up
- 48 hours vs baseline
Methodological detailscore laboratory, multicentre (18 US sites)
- Core laboratory
- Multicentre (18 US sites)
Primary result
As reported in the abstract
Segmental PA branches with total or subtotal occlusions · 48 hours
P < 0.0001
Further findings
Proximal pulmonary artery (PA) branches with total or subtotal occlusion, baseline vs 48 hours post-PM-CDT
- Proximal PA branch total or subtotal occlusions decreased from 28.7% to 11.0%
- P < 0.0001
Correlation of occlusion reduction with reduction in RV/LV ratio
- Segmental artery occlusions: correlation coefficient 0.287 (95% CI 0.102-0.452)
- P = 0.0026
- Proximal PA arteries: correlation coefficient 0.132 (95% CI 0.059-0.314), not significant
- P = 0.173
Original publication
Effect of Pharmacomechanical Catheter-Directed Thrombolysis on Segmental Artery Occlusions: Insights From the RESCUE Trial. JACC Adv. Published 20 October 2023. doi:10.
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