Arrhythmias & electrophysiology
Effect of Semaglutide on Atrial Arrhythmias Recurrence Following Ablation for Atrial Fibrillation: A Prospective Study
Main finding · Freedom from atrial arrhythmia recurrenceResult — go to the resultHR for atrial arrhythmia recurrence 0.68 95% CI 0.49–0.95Authors' conclusion
Semaglutide treatment following catheter ablation for atrial fibrillation is associated with a lower rate of atrial arrhythmia recurrence over 12 months and may lead to improvements in weight and glycated hemoglobin levels.
Study context
- Population
- Patients with BMI ≥24 kg/m² and T2DM undergoing first AF ablation, January 2022–March 2024
- Participants
- 437 patients
- Exposure
- Semaglutide vs control after AF ablation
- Semaglutiden = 158
- Controln = 279reference
- Outcome
- Freedom from atrial arrhythmia recurrence after the 3-month blanking period
- Follow-up
- 12-month follow-up
Methodological detailsconsecutive sample, non-randomised (allocation by patient preference), Baseline imbalance: semaglutide group had higher BMI (27.5 [2.2] vs 27.0 [2.4]; P=0.038) and glycated hemoglobin (8.0 [1.0] vs 7.6 [1.1]; P<0.001)
- Consecutive sample
- Non-randomised (allocation by patient preference)
- Baseline imbalance: semaglutide group had higher BMI (27.5 [2.2] vs 27.0 [2.4]; P=0.038) and glycated hemoglobin (8.0 [1.0] vs 7.6 [1.1]; P<0.001)
Main finding
Freedom from atrial arrhythmia recurrence · 12-month follow-up after 3-month blanking period
HR for atrial arrhythmia recurrence
0.68
95% CI 0.49–0.95
P = 0.030
Semaglutidevs Control
HR for atrial arrhythmia recurrence 0.68 (95% CI 0.49–0.95); P = 0.030
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Semaglutide | Control | P value |
|---|---|---|---|
| Weight loss · 12 months | −8.2% (SD 3.2) | −4.6% (SD 2.9) | P < 0.001 |
| Reduction in glycated hemoglobin · 12 months | −1.3% (SD 0.8) | −0.6% (SD 0.8) | P < 0.001 |
Original publication
Effect of Semaglutide on Atrial Arrhythmias Recurrence Following Ablation for Atrial Fibrillation: A Prospective Study. Circ Arrhythm Electrophysiol. Published 9 October 2025. doi:10.
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