Valvular & structural heart disease
Effect of Transcatheter Aortic Valve Implantation (TAVI) on Epicardial Functional Indices and Their Relationship to Coronary Microvascular Function
Authors' conclusion
TAVI is associated with a small but significant reduction in FFR and RFR immediately post-procedure. Overall, the agreement between pre- and post-TAVI values of FFR was higher compared with resting indices.
Study context
- Population
- Patients with severe aortic stenosis undergoing TAVI, measurements in the left anterior descending arterypatients included
- Participants
- 126 patients
- Comparison
- before and immediately after transcatheter aortic valve implantation
Pooled result
As reported in the abstract
RFR and FFR · Immediately post-TAVI
| Group | Pd/Pa | RFR and FFR (RFR) | Fractional flow reserve (FFR) |
|---|---|---|---|
| Pre-TAVI | 0.93±0.04 | 0.90±0.07 | 0.89±0.07 |
| Post-TAVI | 0.88±0.08 | 0.88±0.08 |
Pd/Pa
Pre-TAVI0.93±0.04
Post-TAVINot reported in the abstract
RFR and FFR (RFR)
Pre-TAVI0.90±0.07
Post-TAVI0.88±0.08
Fractional flow reserve (FFR)
Pre-TAVI0.89±0.07
Post-TAVI0.88±0.08
- Small but significant decrease for both RFR and FFR
- P < 0.05 for all
Further pooled results
Coronary flow reserve and microvascular resistance reserve
- Remained unchanged
Vessels positive by established cutoff values
- FFR positive
- 16 (12.7%)
- Pd/Pa positive
- 35.7%
- RFR positive
- 43.7%
- P <0.001
Concordance between pre- and post-TAVI values
- FFR
- 92.8%
- Pd/Pa
- 75.4%
- RFR
- 73.8%
- P <0.001 for both
Disagreement between resting and hyperemic indices
- Remained unchanged, regardless of the presence of coronary microvascular dysfunction
Original publication
Effect of TAVI on Epicardial Functional Indices and Their Relationship to Coronary Microvascular Function. Circ Cardiovasc Interv. Published 11 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it