Valvular & structural heart disease
Absolute coronary flow and microvascular resistance before and after transcatheter aortic valve implantation
Authors' conclusion
Immediately after TAVI, no changes occurred in absolute coronary flow or coronary flow reserve. Over time, the remodelling of the left ventricle is associated with increased hyperaemic perfusion.
Study context
- Population
- Patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) with non-obstructive CAD in the LAD20 (39%) with 6-month follow-up
- Participants
- 51 patients
- Exposure
- Before vs after TAVI and at 6-month follow-up
- Outcome
- Change in absolute coronary flow (Q) and microvascular resistance (Rμ) in the LAD at rest and during hyperaemia, by continuous intracoronary thermodilution
- Follow-up
- before and after TAVI, and at 6-month follow-up
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Resting and hyperaemic flow and resistance
- No changes in resting and hyperaemic flow and resistance before and after TAVI nor after 6 months
Observational data: associations, not effects.
Further findings
Median, mL/min/g
| Outcome | Pre-TAVI | After TAVI | Follow-up | P value | |
|---|---|---|---|---|---|
| Hyperaemic perfusion (QN,hyper) · 6-month follow-up · significant increase with reverse LV remodelling | 0.86 | Not reported in the abstract | 1.20 (IQR 0.99–1.32) | P = 0.008 | After TAVI: not reported in the abstract |
| Resting perfusion (QN,rest) · 6-month follow-up | 0.34 (IQR 0.30–0.48) | Not reported in the abstract | 0.47 (IQR 0.36–0.67) | P = 0.06 | After TAVI: not reported in the abstract |
Original publication
Absolute coronary flow and microvascular resistance before and after transcatheter aortic valve implantation. EuroIntervention. Published 7 October 2024. doi:10.
Summarised from the published abstract; every number is checked against it