Heart failure & cardiomyopathies
Effect of Training on Vascular Function and Repair in Heart Failure With Preserved Ejection Fraction
Authors' conclusion
In patients with HFpEF, high augmentation index was common, but endothelial function and levels of endothelium-repairing cells were normal in most patients. Aerobic exercise training did not change vascular function or cellular endothelial repair.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)
- Participants
- 180 patients
- Comparison
- High-intensity interval training (HIIT) vs moderate-intensity continuous training (MICT) vs guideline control
- Primary endpoint
- Vascular function and repair (peripheral arterial tonometry, flow-mediated dilation, augmentation index, endothelial progenitor cells and angiogenic T cells)
- Follow-up
- 3 and 12 months
Primary result
As reported in the abstract
3 or 12 months
- Parameters did not change significantly after 3 or 12 months of HIIT or MICT
Further findings
Abnormal values at baseline
- Augmentation index abnormal
- 66%
- Peripheral arterial tonometry abnormal
- 17%
- Flow-mediated dilation abnormal
- 25%
- Endothelial progenitor cells abnormal
- 42%
- Angiogenic T cells abnormal
- 18%
- Abnormal = outside 90% of published sex-specific reference values
Vascular parameters, high training adherence (subgroup)
- Results remained unchanged
Original publication
Effect of Training on Vascular Function and Repair in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. Published 1 March 2023. doi:10.
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