Heart failure & cardiomyopathies
Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials
Authors' conclusion
Baseline NO metabolite profile was unfavourable in patients with HF and lower VO2peak or higher NT-proBNP. We did not find a significant influence of HIIT or MCT on NO metabolites at 3 and 12 months.
Study context
- Population
- Patients with HFrEF (SMARTEX-HF) and HFpEF (OptimEx-Clin)206 HFrEF, 160 HFpEF
- Comparison
- High-intensity interval training (HIIT) vs moderate continuous training (MCT) vs control in HFrEF and HFpEF
- Primary endpoint
- Change in plasma NO metabolites (L-arginine, homoarginine (hArg), ADMA, SDMA)
- Follow-up
- 3 months of supervised exercise training and 12-month follow-up
Primary result
As reported in the abstract
Change in NO metabolite plasma levels · 3 and 12 months
Changes not significantly different between HIIT, MCT and control group (CG), in HFrEF or HFpEF
pgroup×time > 0.05
Further findings
Baseline hArg, HFrEF vs HFpEF · significantly higher in HFrEF
P < 0.001
Baseline ADMA, HFrEF vs HFpEF · significantly higher in HFrEF
P < 0.001
Associations of nitric oxide (NO) metabolites
- Several significant associations with VO2peak and NT-proBNP, but not with endothelial function (reactive hyperaemia index, flow-mediated dilation)
Original publication
Effects of exercise training on nitric oxide metabolites in heart failure with reduced or preserved ejection fraction: a secondary analysis of the SMARTEX-HF and OptimEx-Clin trials. Eur J Prev Cardiol. Published 14 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →