Acute cardiac care & resuscitationRandomised controlled trial
Effect of vascular access strategy on long-term outcomes in patients with out-of-hospital cardiac arrest: a randomised clinical trial
- randomised clinical trial
Authors' conclusion
Long-term outcomes were similar between patients who received initial intraosseous versus intravenous vascular access during adult out-of-hospital cardiac arrest. These findings do not support a difference in patient outcomes between the two vascular access strategies.
Study context
- Population
- Adults with non-traumatic out-of-hospital cardiac arrest, in whom vascular access was indicatedpatients included in the main manuscript primary analyses, three lost to follow-up for 1-year survival
- Participants
- 1,479 adults
- Comparison
- initial intraosseous versus intravenous vascular access
Primary result
Survival · 1 year
Risk ratio
1.24
95% CI 0.91–1.67
Events by treatment group
intraosseous group vs intravenous group
risk ratio 1.24 (95% CI 0.91–1.67)
As reported in the abstract
Further findings
| Outcome | intraosseous group | intravenous group | risk ratio (95% CI) | |
|---|---|---|---|---|
| Survival with a favourable neurological outcome (modified Rankin Scale score of 0-3) · 1 year | 10% | 8% | 1.28 (0.93–1.77) | |
| 0.512Risk ratio (log scale) |
Mean
| Outcome | intraosseous group | intravenous group | mean difference (95% CI) | |
|---|---|---|---|---|
| EQ-5D-5L numeric score among survivors · among survivors | 83 | 76 | 7 (1–13) | |
| −1001020Difference (linear scale) |
Original publication
Effect of vascular access strategy on long-term outcomes in patients with out-of-hospital cardiac arrest: a randomised clinical trial. Resuscitation. Published 10 April 2026. doi:10.1016/j.resuscitation.2026.111087
Summarised from the published abstract; every number is checked against it