Acute cardiac care & resuscitationRandomised controlled trial
Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest
- Randomised controlled trial
Authors' conclusion
There was no significant difference in sustained return of spontaneous circulation between initial intraosseous and intravenous vascular access in adults who had out-of-hospital cardiac arrest.
Study context
- Population
- Adults with nontraumatic OHCA1,479 in primary analysis
- Participants
- 1,506 adults
- Comparison
- Initial intraosseous vs intravenous vascular access
- Intraosseousn = 731
- Intravenousn = 748reference
- Primary endpoint
- Sustained return of spontaneous circulation
Primary result
As reported in the abstract
Relative risk
1.06
95% CI 0.90–1.24
P = 0.49
Events by treatment group
Intraosseous vs Intravenous
RR 1.06 (95% CI 0.90–1.24); P = 0.49
Secondary outcomes
| Outcome | Intraosseous | Intravenous | RR (95% CI) | |
|---|---|---|---|---|
| Survival · 30 days | 12% | 10% | 1.16 (0.87–1.56) | |
| Survival with favourable neurologic outcome (modified Rankin 0–3) · 30 days | 9% | 8% | 1.16 (0.83–1.62) | |
| 0.512Relative risk (log scale) |
Vascular access established within two attempts
Original publication
Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest. N Engl J Med. Published 31 October 2024. doi:10.1056/nejmoa2407616
Summarised from the published abstract; every number is checked against it