Heart failure & cardiomyopathies
The Effect of Sodium–Glucose Cotransporter 2 Inhibitors on Left Cardiac Remodelling in Heart Failure with Reduced Ejection Fraction: Systematic Review and Meta-Analysis
Authors' conclusion
Sodium-glucose cotransporter 2 inhibitors improve cardiac structure and function in patients with HFrEF.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF)
- Participants
- 555 patients6 trials
- Comparison
- SGLT2i vs control
- Outcome
- Left cardiac structure and function (remodelling indices)
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
SGLT2i vs ControlWMD, ml (95% CI)P value
LVEDV
−17.07(−23.84 to −10.31)
P < 0.001LVESV
−15.63(−26.15 to −5.12)
P = 0.004SGLT2i vs ControlWMD, ml/m2 (95% CI)P value
LVEDV index
−5.62(−10.28 to −0.97)
P = 0.02LVESV index
−6.90(−10.68 to −3.11)
P = 0.001Left atrial volume index
−2.19(−4.26 to −0.11)
P = 0.04SGLT2i vs ControlWMD, % (95% CI)P value
LVEF
2.71(0.70–4.72)
P = 0.008SGLT2i vs ControlWMD, g/m2 (95% CI)P value
LV mass index; non-significant trend towards a reduction
−6.25(−12.79 to 0.28)
P = 0.06- No significant impact on LV global longitudinal strain
- WMD: 0.21% [−0.25, 0.67]; p = 0.38
Original publication
The Effect of Sodium–Glucose Cotransporter 2 Inhibitors on Left Cardiac Remodelling in Heart Failure with Reduced Ejection Fraction: Systematic Review and Meta-Analysis. Eur J Heart Fail. Published 18 January 2024. doi:10.
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