Heart failure & cardiomyopathies
Limitations of apical sparing pattern in cardiac amyloidosis: a multicentre echocardiographic study
Authors' conclusion
Apical sparing did not prove to be a CA-specific biomarker for accurate identification of CA, when compared with clinically similar CTRLs with no CA.
Study context
- Population
- Patients with confirmed or suspected (ruled out) cardiac amyloidosis; echocardiographic measurements by AI software, audited by an experienced echocardiographer
- Participants
- 544 / 200 / 174
- Comparison
- Confirmed cardiac amyloidosis (CA) vs CTRL patients
- CAn = 544
- CTRLn = 200reference
- Healthy CTRLn = 174
- Outcome
- Diagnostic accuracy of apical sparing ratio (ASR) and common echocardiographic parameters for differentiating CA from CTRL patients
Methodological detailsmulticentre
- Multicentre
Performance
As reported in the abstract
Diagnostic accuracy for CA vs CTRL
| Test or model | AUC | Optimal cut-off | Sensitivity | Specificity |
|---|---|---|---|---|
| ASR | 0.74 | 1.67 | 72% | 66% |
| Relative wall thickness | 0.77 |
AUC
ASR0.74
Relative wall thickness0.77
Optimal cut-off
ASR1.67
Relative wall thickness— not stated in the abstract
Sensitivity
ASR72%
Relative wall thickness— not stated in the abstract
Specificity
ASR66%
Relative wall thickness— not stated in the abstract
- Apical sparing present in CTRL patients
- 32%
- Apical sparing present in healthy subjects
- 6%
Further findings
| Outcome | CA | CTRL | P value |
|---|---|---|---|
| LV GLSCA vs CTRL · more impaired in CA | −13.9 ± 4.6 % | −15.9 ± 2.7 % | P < 0.0005 |
| ASRCA vs CTRL · higher in CA | 2.4 ± 1.2 | 1.7 ± 0.9 | P < 0.0005 |
Original publication
Limitations of apical sparing pattern in cardiac amyloidosis: a multicentre echocardiographic study. Eur Heart J Cardiovasc Imaging. Published 18 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →