Effects of Aerobic Exercise on Cardiorespiratory Fitness and Cardiovascular Risk Factors in Long-Term Breast Cancer Survivors: A Randomized Controlled Trial
Authors' conclusion
Although aerobic exercise improves CRF in anthracycline-treated long-term BCS, the response was less than one-half that observed in cancer-naive subjects.
Study context
- Population
- Anthracycline-treated long-term breast cancer survivors (BCS) and cancer-naive women140 BCS, 69 cancer-naive
- Comparison
- BCS exercise vs BCS usual care vs Non-cancer
- Non-cancern = 69
- Primary endpoint
- Cardiorespiratory fitness (Vo2peak)
- Follow-up
- Baseline to post-exercise intervention
Methodological details2-arm, non-randomised cancer-naive comparison group
- 2-arm
- Non-randomised cancer-naive comparison group
Primary result
As reported in the abstract
Change in Vo2peak
BCS exercise
1.2
± 2.6 · mL·kg-1·min-1
BCS usual care
0.01
± 2.5 · mL·kg-1·min-1
Non-cancer
2.6
± 2.5 · mL·kg-1·min-1
Mean difference (95% CI)P value
BCS exercise vs BCS usual care
1.3(0.5–2.1)
P = 0.002BCS exercise vs Non-cancer
−1.4(−2.2 to −0.5)
P = 0.003Secondary outcomes
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Subjective vitality | 2.56 (1.22–3.90) | P < 0.001 | |
| Satisfaction with life | 1.68 (0.43–2.93) | P = 0.009 | |
| −2024Difference (linear scale) |
CV risk factors (cardiometabolic biomarkers, body composition)
- No changes in CV risk factors
Original publication
Effects of Aerobic Exercise on Cardiorespiratory Fitness and Cardiovascular Risk Factors in Long-Term Breast Cancer Survivors: A Randomized Controlled Trial. JACC CardioOncol. doi:10.
Summarised from the published abstract; every number is checked against it