Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients With Primary Breast Cancer: A Randomized Controlled Trial
Authors' conclusion
Short-term exercise training, independently of dosing schedule, is associated with modest improvements in cardiorespiratory fitness in patients previously treated for early-stage breast cancer.
Study context
- Population
- Postmenopausal patients with posttreatment primary breast cancer (2.8 years after adjuvant therapy) with impaired VO2peak
- Participants
- 174 patients
- Comparison
- Linear or nonlinear supervised exercise training vs stretching attention control
- Primary endpoint
- Change in VO2peak (mL O2·kg-1·min-1) from baseline to after intervention
- Follow-up
- 16 weeks
Methodological detailsparallel-group, attention-controlled
- Parallel-group
- Attention-controlled
Primary result
As reported in the abstract
Change in VO2peak vs attention control
LET
0.6
± 1.7 · mL O2·kg-1·min-1
NLET
0.8
± 1.8 · mL O2·kg-1·min-1
- LET
- increase 0.6 mL O2·kg-1·min-1; P = 0.05
- NLET
- increase 0.8 mL O2·kg-1·min-1; P = 0.07
Secondary outcomes
Mean
| Outcome | LET | NLET | Attention control |
|---|---|---|---|
| Mean attendance | 75% | 80% | 64% |
VO2peak responders (Δ ≥1.32 mL O2·kg-1·min-1)
- ≈40% of patients in both exercise regimens were responders
Patient-reported outcomes
- NLET improved all patient-reported outcomes vs attention control
Safety
Serious adverse events
- No serious adverse events observed
Original publication
Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients With Primary Breast Cancer: A Randomized Controlled Trial. Circulation. Published 17 February 2020. doi:10.
Summarised from the published abstract; every number is checked against it