Valvular & structural heart disease
The effects of low-dose colchicine on the progression of aortic valve stenosis: Rationale, design, and baseline characteristics of the Colchicine and Inflammation in Aortic Stenosis (CHIANTI) trial
Study context
- Population
- Patients with moderate AS
- Participants
- 150 patients
- Planned comparison
- Low-dose colchicine vs placebo
- Primary endpoint
- Change in aortic valve calcium score on CT
- Follow-up
- 24 months
Methodological detailsrationale, design and baseline characteristics, investigator-initiated, placebo-controlled, double-blind, multicentre, 1:1 randomisation, 2-week run-in phase, Baseline coronary computed tomography (CT) angiography, 18F-NaF PET-CT and echocardiography, repeated after 24 months, Secondary endpoints: change in aortic valve 18F-NaF uptake on PET-CT (target-to-background ratio corrected); change in peak aortic jet velocity on echocardiography
- Rationale, design and baseline characteristics
- Investigator-initiated
- Placebo-controlled
- Double-blind
- Multicentre
- 1:1 randomisation
- 2-week run-in phase
- Baseline coronary CT angiography, 18F-NaF PET-CT and echocardiography, repeated after 24 months
- Secondary endpoints: change in aortic valve 18F-NaF uptake on PET-CT (target-to-background ratio corrected); change in peak aortic jet velocity on echocardiography
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The effects of low-dose colchicine on the progression of aortic valve stenosis: Rationale, design, and baseline characteristics of the Colchicine and Inflammation in Aortic Stenosis (CHIANTI) trial. Am Heart J. Published 12 July 2025. doi:10.
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