Valvular & structural heart disease
Long-term survival after transcatheter aortic valve implantation in the modern era compared with the general population—a nationwide Danish cohort study
Authors' conclusion
Our findings suggest that TAVI was associated with long-term mortality and hospitalization rates comparable to the general population. Stratified by age, mortality was higher among TAVI patients <80 years and lower among those ≥80 years. These findings support patient selection, safety, and long-term outcomes of TAVI.
Study context
- Population
- All patients undergoing transcatheter aortic valve implantation (TAVI) in Denmark (2015–23) and age- and sex-matched controls from the general population
- Participants
- 7,250 vs 29,000
- Exposure
- Patients undergoing TAVI vs controls from the general population
- TAVI groupn = 7,250
- Controlsn = 29,000reference
- Outcome
- 5-year all-cause mortality (absolute risk of death)
- Follow-up
- 5 years
Methodological detailsmatched on age and sex with controls from the general population (1:4)
- Matched on age and sex with controls from the general population (1:4)
Main finding
As reported in the abstract
Adjusted hazard ratio
0.95
95% CI 0.90–1.01
By group
TAVI groupvs controls
adjusted hazard ratio 0.95 (95% CI 0.90–1.01)
Observational data: associations, not effects.
Further findings
All-cause mortality stratified by age
- Higher risk of death among the TAVI group aged <80 years compared with controls
- Patients aged ≥80 years showed a lower risk of death
5-year all-cause hospitalization burden
- Patients undergoing TAVI experienced longer and more frequent hospitalizations compared with controls, while the relative difference decreased over time
Original publication
Long-term survival after transcatheter aortic valve implantation in the modern era compared with the general population—a nationwide Danish cohort study. Eur Heart J Qual Care Clin Outcomes. Published 11 July 2025. doi:10.
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