Valvular & structural heart disease
Effects of intensive blood pressure control on left ventricular hypertrophy in aortic valve disease
Authors' conclusion
Among hypertensive patients with AV disease, intensive hypertensive therapy resulted in a significant reduction in LV hypertrophy, although progression of AV disease was similar between the treatment groups.
Study context
- Population
- Asymptomatic hypertensive patients with mild to moderate aortic stenosis (AS) or aortic regurgitationor aortic regurgitation 35
- Participants
- 128 patients
- Comparison
- Intensive vs standard blood pressure (BP) control
- Primary endpoint
- Change in LV mass from baseline
- Follow-up
- 24-month follow-up
Primary result
As reported in the abstract
Change in LV mass · 24 months
| Group | Value | Left ventricle (LV) mass baseline to 24 months |
|---|---|---|
| Intensive therapy | mean change −3.9 (SD 20.2) g | 189.5 ± 41.3 to 185.6 ± 41.5 g (P = .19) |
| Standard therapy | mean change 10.3 (SD 20.4) g | 183.8 ± 38.3 to 194.0 ± 46.4 g (P < .01) |
Value
Intensive therapymean change −3.9 (SD 20.2) g
Standard therapymean change 10.3 (SD 20.4) g
Left ventricle (LV) mass baseline to 24 months
Intensive therapy189.5 ± 41.3 to 185.6 ± 41.5 g (P = .19)
Standard therapy183.8 ± 38.3 to 194.0 ± 46.4 g (P < .01)
- Intensive therapy vs Standard therapy: P = 0.0007
Secondary outcomes
Systolic BP · 24 months
- Systolic BP — Rapid and sustained difference in SBP between strategies
- P < .05
Change in LV mass index
- Increase significantly greater with standard therapy
- P = 0.01
Changes in aortic valve (AV) disease severity, LV volumes, EF and global longitudinal strain (GLS)
- No significant differences between groups
Death or AV surgery
- No patient died or underwent AV surgery in either group
Original publication
Effects of intensive blood pressure control on left ventricular hypertrophy in aortic valve disease. Am Heart J. Published 23 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it