Valvular & structural heart disease
Prognostic Implications of Functional Tricuspid Regurgitation in Asymptomatic Degenerative Mitral Regurgitation
Authors' conclusion
Among asymptomatic patients with significant DMR, ≥moderate FTR is frequent and independently associated with higher mortality, independently of traditional guideline-based risk factors. These findings suggest that ≥moderate FTR should lead to consideration of early mitral surgery to improve outcomes.
Study context
- Population
- Asymptomatic patients with moderate or severe degenerative mitral regurgitation (DMR)asymptomatic patients with moderate or severe DMR, mean age 64 ± 15 years, 25% female
- Participants
- 1,249 patients
- Exposure
- Functional tricuspid regurgitation (FTR) grades in asymptomatic DMR
Main finding
As reported in the abstract
Prevalence of FTR grades
Observational data: associations, not effects.
Further findings
Mortality, adjusted
| Comparison | HR (CI) | P value | |
|---|---|---|---|
| ≥moderate FTR | 2.08 (1.17–3.72) | P = 0.013 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Absent/trivial FTR | Mild | Moderate | Severe FTR | Estimate | P value | |
|---|---|---|---|---|---|---|---|
| Survival · 5-year | 96 ± 1% | Not reported in the abstract | 64 ± 4% | 65 ± 4% | mild: not reported in the abstract |
- Survival: P < 0.001
- Mortality, adjusted: adjusted for age, left ventricular dilatation and dysfunction, DMR severity, left atrial dilatation, and pulmonary hypertension
Characteristics by FTR grade
- Higher FTR grades: older, more often female, higher EuroScore II, larger left atrial volumes, more atrial fibrillation
- all P < 0.05
Sensitivity analysis
- Stable impact of ≥moderate FTR among patients with/without pulmonary hypertension, in women and men and for any other subset
Post-operative survival after mitral valve surgery
- Similar between no/trivial FTR and ≥moderate or severe FTR
- P = 0.76
Original publication
Prognostic Implications of Functional Tricuspid Regurgitation in Asymptomatic Degenerative Mitral Regurgitation. ESC Heart Fail. Published 23 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it