Heart failure & cardiomyopathies
Effects of Multifaceted Optimization Management for Chronic Heart Failure: A Multicentre, Randomized Controlled Study
Authors' conclusion
It is likely that the multifaceted optimization programme used in this study is feasible would benefit patients with CHF in NYHA functional classification, readmission for worsening heart failure, plasma NT-proBNP level, LVEF, patient TCM syndrome scores, and quality of life.
Study context
- Population
- Patients with chronic heart failure (CHF) at nine research sites
- Participants
- 256 patients9 sites
- Comparison
- Multifaceted optimization programme vs conventional programme
- Primary endpoint
- Change in New York Heart Association (NYHA) functional classification
- Follow-up
- During 24 weeks of treatment
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Improvement in NYHA functional classification
- Optimization vs Control: P = 0.023
- Optimization vs Control: P < 0.001
Further findings
| Outcome | P value |
|---|---|
| Receipt of beta-blockers and ACEi or ARBs (HFrEF)Optimization vs Control · beta-blockers; more likely with optimization | P = 0.038 |
| Receipt of beta-blockers and ACEi or ARBs (HFrEF)Optimization vs Control · ACEi or ARBs; more likely with optimization | P = 0.013 |
Readmission for MACE and for worsening HF, NT-proBNP, left ventricular ejection fraction (LVEF), traditional Chinese medicine (TCM) syndrome scores, quality of life
- Superior performance with optimization vs conventional programme
Original publication
Effects of Multifaceted Optimization Management for Chronic Heart Failure: A Multicentre, Randomized Controlled Study. ESC Heart Fail. Published 30 September 2022. doi:10.
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