Heart failure & cardiomyopathies
Familial Risk of Dilated and Hypertrophic Cardiomyopathy: A National Family Study in Sweden
Authors' conclusion
Familial risk of HCM and DCM is high and associated with genetic resemblance, with strongest aggregations observed in relatives of affected females with HCM, whereas this association was distinctly attenuated for DCM.
Study context
- Population
- Full-siblings, half-siblings and cousin pairs born to Swedish parents 1932–201510,272 DCM, 3769 hypertrophic cardiomyopathy (HCM)
- Participants
- 6,334,979 participants
- Exposure
- Relatives of individuals with DCM/HCM vs relatives of individuals without DCM/HCM
- Full-siblingsn = 5,577,449
- Half-siblingsn = 1,321,414
- Cousinsn = 3,952,137
- Outcome
- Familial incidence (adjusted odds ratios (ORs)) of DCM and HCM in relatives of affected individuals
Methodological detailsregister-based, national
- Register-based
- National
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
Full-siblingsvs Relatives of unaffectedDCM
5.35(4.85–5.90)
Half-siblingsvs Relatives of unaffectedDCM
2.68(1.86–3.87)
Cousinsvs Relatives of unaffectedDCM
1.72(1.12–2.64)
Full-siblingsvs Relatives of unaffectedHCM
42.44(37.66–47.82)
Half-siblingsvs Relatives of unaffectedHCM
32.70(21.32–50.15)
Cousinsvs Relatives of unaffectedHCM
36.96(29.50–46.31)
Observational data: associations, not effects.
Further findings
Familial risk by sex of affected individual (sex-stratified)
- Relatives of affected females more likely affected than relatives of affected males; stronger aggregation for HCM
Original publication
Familial Risk of Dilated and Hypertrophic Cardiomyopathy: A National Family Study in Sweden. ESC Heart Fail. Published 28 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →