Effects of paediatric human immunodeficiency virus (HIV) infection on childhood vasculature
Main finding · cIMTResult — go to the resultDifference 70.4 µm 95% CI 32.1–108.7Authors' conclusion
ART-naive HIV infection in children is associated with increased cIMT. Children with ART-controlled HIV may have increased arterial stiffness, although further confirmation is required.
Study context
- Population
- Children with vertically acquired HIV infection and healthy children in Jakarta, Indonesia114 HIV-infected, 51 healthy
- Participants
- 56 / 58 / 51
- Exposure
- Antiretroviral therapy (ART)-naive or ART-treated HIV infection vs healthy children
- ART-naiven = 56
- ART treatedn = 58
- Healthyn = 51reference
- Outcome
- cIMT, distensibility and elastic modulus by vascular ultrasound
Main finding
cIMT
Difference
70.4 µm
95% CI 32.1–108.7
P < 0.001
ART-naive vs Healthy
difference 70.4 µm (95% CI 32.1–108.7); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (kPa) (95% CI) | P value | |
|---|---|---|---|
| Elastic modulus, ART-exposed with controlled HIV (CD4+ ≥200/mm3 or CD4+ ≥15%) (subgroup)ART treated vs Healthy · adjusted | 37.9 (6.5–69.3) | P = 0.02 | |
| Elastic modulus, ART-exposed with controlled HIV (CD4+ ≥200/mm3 or CD4+ ≥15%) (subgroup)ART treated vs Healthy · further adjusted for hs-CRP | 35.5 (4.2–66.8) | P = 0.03 | |
| −50050100Difference, kPa (linear scale) |
Distensibility
- Not significantly different between HIV infected (ART-naive or -exposed) and healthy children
Original publication
Effects of paediatric HIV infection on childhood vasculature. Eur Heart J. Published 7 January 2016. doi:10.
Summarised from the published abstract; every number is checked against it