Heart failure & cardiomyopathies
Effects of Pharmacological Interventions on Mortality in Patients with Takotsubo Syndrome: A Report from the SWEDEHEART Registry
Authors' conclusion
Our findings suggest that some medications commonly used to treat TS are associated with higher mortality, while others have lower mortality.
Study context
- Population
- Patients with takotsubo syndrome undergoing coronary angiography, SWEDEHEART registry, 2009–2016among 228,263 in registry
- Participants
- 1,724 patients
- Exposure
- Pharmacological interventions vs none, by drug class
- Outcome
- All-cause mortality (short- and long-term)
Methodological detailsSWEDEHEART registry
- SWEDEHEART registry
Main finding
As reported in the abstract
All-cause mortality by drug class
- Kaplan-Meier all-cause mortality at 30 days
- 2.5%
- Kaplan-Meier all-cause mortality at 6 years
- 16.6%
- IV inotropes, 30-day mortality, HR
- 9.92 (P < 0.001)
- IV diuretics, 30-day mortality, HR
- 3.22 (P = 0.001)
- ACEi, long-term mortality, HR
- 0.60 (P = 0.025)
- Statins, long-term mortality, HR
- 0.62 (P = 0.040)
- Unfractionated and low-molecular-weight heparins, 30-day mortality, HR
- 0.63 (P = 0.01)
Observational data: associations, not effects.
Original publication
Effects of Pharmacological Interventions on Mortality in Patients with Takotsubo Syndrome: A Report from the SWEDEHEART Registry. ESC Heart Fail. Published 7 March 2024. doi:10.
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