Heart failure & cardiomyopathies
Arterial hypertension in patients with takotsubo syndrome: prevalence, long-term outcome, and secondary preventive strategies: a report from the Takotsubo Italian Network register
Main finding · All-cause death or TTS recurrenceResult — go to the resultAdjusted hazard ratio 0.69 95% CI 0.49–0.99Authors' conclusion
In this TTS study, HT did not affect the long-term risk of adverse events but increased the probability of benefit from BB treatment after discharge.
Study context
- Population
- Consecutive patients with takotsubo syndrome, Takotsubo Italian Network registerHypertension (HT) in 66%
- Participants
- 903 patients
- Exposure
- HT vs no HT; BB or renin-angiotensin-aldosterone system inhibitors (RAASi) at discharge vs none
- Outcome
- Composite of:
- All-cause death
- TTS recurrence
- Follow-up
- Longest available (median 2 years)
Methodological detailsmulticentre, consecutive patients, propensity score weighting
- Multicentre
- Consecutive patients
- Propensity score weighting
Main finding
All-cause death or TTS recurrence · median 2-year follow-up
Adjusted hazard ratio
0.69
95% CI 0.49–0.99
BB vs No BB
aHR 0.69 (95% CI 0.49–0.99)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause death or TTS recurrence with BB, by HT (subgroup) — BB vs No BB · HT | 0.37 (0.24–0.56) | |
| All-cause death or TTS recurrence with BB, by HT (subgroup) — BB vs No BB · no HT | 1.83 (0.92–3.64) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- All-cause death or TTS recurrence with BB, by HT (subgroup): interaction P<0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Arterial hypertension in patients with takotsubo syndrome: prevalence, long-term outcome, and secondary preventive strategies: a report from the Takotsubo Italian Network register. Eur J Prev Cardiol. Published 18 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it