Arrhythmias & electrophysiology
Effects of pulsed field ablation on autonomic nervous system in paroxysmal atrial fibrillation: A pilot study
Authors' conclusion
PFA does not induce nerve injury during pulmonary vein isolation for paroxysmal AF.
Study context
- Population
- Patients with paroxysmal atrial fibrillation (AF) undergoing pulsed field ablation (PFA), August 2021–November 202172 pulmonary veins
- Participants
- 18 patients
- Outcome
- Effect of PFA on the autonomic nervous system (nerve injury biomarkers, heart rate variability)
Methodological detailssingle-group
- Single-group
Main finding
As reported in the abstract
- Serum nerve injury biomarkers unchanged preablation, immediately postablation and 24 h after ablation
- all P >.05
- Heart rate variability preablation vs 30 days postablation did not differ
- all P >.05
Observational data: associations, not effects.
Further findings
Total procedural time
- Mean total procedural time (minutes)
- 64.1 ± 18.2
Fluoroscopy time
- Mean fluoroscopy time (minutes)
- 12.3 ± 3.5
Freedom from arrhythmia · 8 months
- Kaplan-Meier estimate of freedom from arrhythmia
- 83% ± 9%
Acute PV isolation
- Acute electrical isolation of pulmonary veins (n = 72)
- 100%
Safety
Acute cerebral microembolus events (diffusion-weighted imaging) · postablation
- No acute cerebral microembolus events
Other procedure-related complications
- No other procedure-related complications
Original publication
Effects of pulsed field ablation on autonomic nervous system in paroxysmal atrial fibrillation: A pilot study. Heart Rhythm. Published 24 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →