Heart failure & cardiomyopathies
Effects of Septal Myectomy on Left Atrial and Left Ventricular Function in Obstructive Hypertrophic Cardiomyopathy
Authors' conclusion
As haemodynamic loads due to LV outflow tract obstruction was relieved through surgical septal reduction therapy in patients with symptomatic obstructive HCM, there was a significant reduction in LA volume and restoration of LA mechanical dysfunction. However, LV mechanical dysfunction deteriorated even after surgical septal reduction therapy.
Study context
- Population
- Patients undergoing septal myectomy for symptomatic obstructive hypertrophic cardiomyopathy (HCM), 2006–2022 (excluding simultaneous valve repair/replacement or maze operation)44 analysed
- Participants
- 65 patients
- Exposure
- Before vs 1 year after septal myectomy
- Outcome
- LA and LV function, before vs 1 year after septal myectomy
- Follow-up
- 1 year after surgery
Main finding
As reported in the abstract
1 year after surgery
- Left atrium (LA) volume index decreased significantly (58.1 ± 18.3 vs 45.3 ± 14.6 mL/m²)
- P = 0.001
- LVEF decreased as left ventricle (LV) end-systolic dimension increased (73.8 ± 6.7 vs 62.9 ± 8.3%)
- P < 0.001
- LA strain improved (24.4 ± 9.3 vs 30.5 ± 13.6%)
- P = 0.004
- LV global longitudinal strain deteriorated (−12.6 ± 3.6 vs −11.6 ± 4.3%)
- P = 0.033
- Non-septal longitudinal strain worsened (−14.4 ± 4.3 vs −10.9 ± 8.4%)
- P = 0.005
Observational data: associations, not effects.
Original publication
Effects of Septal Myectomy on Left Atrial and Left Ventricular Function in Obstructive Hypertrophic Cardiomyopathy. ESC Heart Fail. Published 22 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →