Heart failure & cardiomyopathies
Systemic Inflammation is Associated with Myocardial Fibrosis in Patients with Obstructive Hypertrophic Cardiomyopathy
Authors' conclusion
Higher levels of IL-2 and TNF-α were associated with increased histopathological interstitial MF in patients with HCM.
Study context
- Population
- Patients with obstructive hypertrophic cardiomyopathy (HCM) undergoing septal myectomy with complete baseline data
- Participants
- 102 patients
- Exposure
- High MF vs low MF; association of inflammatory markers with MF
- Outcome
- Association of plasma inflammatory markers with histopathological interstitial MF (Masson's trichrome)
Methodological detailshistopathological analysis of septal myectomy samples
- Histopathological analysis of septal myectomy samples
Main finding
As reported in the abstract
Interstitial MF (histopathology), by inflammatory marker
Odds ratio (95% CI)P value
IL-2adjusted for age, sex and other clinical features
1.54(1.10–2.14)
IL-5adjusted for age, sex and other clinical features
1.42(1.02–1.98)
TNF-αadjusted for age, sex and other clinical features
1.33(1.04–1.70)
IL-2additionally adjusted for imaging indicators
1.49(1.06–2.09)
P = 0.021TNF-αadditionally adjusted for imaging indicators
1.35(1.01–1.80)
P = 0.044Observational data: associations, not effects.
Further findings
Plasma IL-2, tumour necrosis factor (TNF)-α and interferon (IFN)-α, high vs low MF
- Significantly higher in high MF vs low MF: IL-2 (as printed)
- 2.3 vs. 4.0 pg/mL
- TNF-α (as printed)
- 3.1 vs. 3.9 pg/mL
- IFN-α (as printed)
- 4.2 vs.4.7 pg/mL
- All P < 0.05
Overall MF
- Range
- 2.5% to 40.7%
- Mean ± SD
- 15.2 ± 8.1%
- Median (IQR)
- 13.0% (9.9%-18.4%)
Late gadolinium enhancement (LGE) on CMR (replacement fibrosis)
- LGE present
- 72 (74.2%) of 97
- No significant correlation between inflammatory markers and presence or extent of LGE
Baseline characteristics, high vs low MF
- High MF had larger left atrial diameter and LVEF
Original publication
Systemic Inflammation is Associated with Myocardial Fibrosis in Patients with Obstructive Hypertrophic Cardiomyopathy. ESC Heart Fail. Published 17 October 2024. doi:10.
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