Effects of Walnut Consumption on Anti-MDA-LDL Antibodies and Immunoglobulins in the WAHA Randomized Trial
Authors' conclusion
Long-term walnut consumption was associated with a modest increase in total serum IgG but had no significant effect on total IgM, MDA-LDL, or antibodies against MDA-LDL. Baseline IgG and IgM concentrations were substantially lower among U.S. participants, suggesting that geographic, environmental, social, or genetic factors may modulate immune biomarkers independently of dietary intervention.
Study context
- Population
- Adults aged 63 to 79 years in Spain and the United Statesparticipants with serum immunoglobulins, MDA-LDL and anti-MDA-LDL antibodies measured
- Participants
- 474 adults
- Comparison
- Walnut-enriched diet vs control diet excluding walnuts for 2 years
Primary result
As reported in the abstract
Participants from the United States had lower total immunoglobulin M (IgM) and immunoglobulin G (IgG) concentrations than participants from Spain
25% lower
Further findings
| Outcome | Increase (95% CI) | P value | |
|---|---|---|---|
| Total serum IgG, U.S. cohort · 2 yearsIncrease with walnut consumption | 11% (0%–24%) | P = 0.040 | |
| Total serum IgG, pooled both cohorts · 2 yearsIncrease with walnut consumption; pooled analysis | 6% (0%–12%) | P = 0.041 | |
| −100102030Difference (linear scale) |
Total IgM and IgG and IgM anti-MDA-LDL concentrations · 2-year study period
- Declined significantly in both the control and intervention groups
Original publication
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