Efficacy and safety of intensive antihypertensive strategy in patients with low diastolic blood pressure: a secondary analysis of a cluster randomised trial
Authors' conclusion
The intensive BP intervention led by non-physician providers is both effective and safe in reducing CVD and mortality across all baseline DBP groups.
Study context
- Population
- General hypertensive population, stratified by baseline diastolic BP (DBP) quartilesdivided into four baseline DBP quartiles
- Participants
- 33,288 participants
- Comparison
- Intervention group vs usual care, stratified by baseline DBP quartiles
Methodological detailssecondary analysis of a cluster randomised trial
- Secondary analysis of a cluster randomised trial
Primary result
As reported in the abstract
Cardiovascular outcomes, by baseline DBP quartile
intervention group vs usual careAdjusted hazard ratio (95% CI)P value
Q1: DBP ≤80.7 mm Hg
0.69(0.58–0.83)
P < 0.001Q2: 80.7-87.3 mm Hg
0.60(0.50–0.71)
P < 0.001Q3: 87.3-94.3 mm Hg
0.59(0.49–0.71)
P < 0.001Q4: >94.3 mm Hg
0.67(0.56–0.78)
P < 0.001Original publication
Efficacy and safety of intensive antihypertensive strategy in patients with low diastolic blood pressure: a secondary analysis of a cluster randomised trial. Heart. Published 9 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →