Efficacy and safety of low levels of low-density lipoprotein cholesterol: trans-ancestry linear and non-linear Mendelian randomization analyses
Authors' conclusion
In British and Chinese populations, we confirmed a linear dose-response relationship of LDL-C with CAD and found potential safety concerns at low LDL-C levels
Study context
- Population
- British (UK Biobank) and Chinese (China-PAR) individuals
- Participants
- 353,232 vs 41,271
- Comparison
- Genetically proxied LDL-C levels
- Britishn = 353,232
- Chinesen = 41,271
- Outcome
- CAD, all-cause mortality and safety outcomes (haemorrhagic stroke, DM, overall cancer, non-CV death, dementia)
Methodological detailslinear and non-linear Mendelian randomization (MR), trans-ancestry
- Linear and non-linear MR
- Trans-ancestry
Main finding
As reported in the abstract
CAD per mmol/L increase in LDL-C (linear MR)
Odds ratio per unit mmol/L increase
1.75
P = 7.57 × 10-52
British
Odds ratio per unit mmol/L increase
2.06
P = 9.10 × 10-3
Chinese
Further findings
Non-linear associations with coronary artery disease (CAD), all-cause mortality and safety outcomes
- No significant non-linear associations above LDL-C minimum of 50 (British) and 20 mg/dL (Chinese)
- Cochran Q P > 0.25
Safety
| Outcome | OR | P value |
|---|---|---|
| Adverse events at LDL-C <70 mg/dL (stratified analysis)British · haemorrhagic stroke; lower LDL-C, higher risk | 0.72 | P = 0.03 |
| Adverse events at LDL-C <70 mg/dL (stratified analysis)British · dementia; lower LDL-C, higher risk | 0.75 | P = 0.03 |
Original publication
Efficacy and safety of low levels of low-density lipoprotein cholesterol: trans-ancestry linear and non-linear Mendelian randomization analyses. Eur J Prev Cardiol. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →