Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users
Authors' conclusion
Statin use and the presence of statin-associated muscle symptoms does not exacerbate exercise-induced muscle injury after moderate exercise. Muscle injury markers were not related to leukocyte CoQ10 levels.
Study context
- Population
- Statin users with and without statin-associated muscle symptoms and controls walking 30, 40 or 50 km/d for 4 consecutive days
- Participants
- 35 / 34 / 31
- Exposure
- Symptomatic vs asymptomatic statin users vs controls during prolonged moderate-intensity exercise
- Symptomatic statin usersn = 35
- Asymptomatic statin usersn = 34
- Controln = 31reference
- Outcome
- Muscle injury markers (lactate dehydrogenase, creatine kinase, myoglobin, cardiac troponin I, NT-proBNP)
- Follow-up
- Baseline and after exercise
Main finding
As reported in the abstract
Muscle injury markers · after exercise
- Comparable at baseline
- P > 0.05
- Increased following exercise
- P < 0.001
- No differences in magnitude of exercise-induced elevations among groups
- P > 0.05
Observational data: associations, not effects.
Further findings
Leukocyte CoQ10 · baseline
- Muscle relaxation time · after exercise · Symptomatic statin users vs Control · increased more in symptomatic statin users
- P = 0.035
- Leukocyte coenzyme Q10 (CoQ10) — Did not differ among groups
- P = 0.20
Muscle pain scores
- Higher at baseline in symptomatic statin users
- P < 0.001
- Increased similarly in all groups following exercise
- P < 0.001
Leukocyte CoQ10 · baseline
- Not related to muscle injury markers, fatigue resistance or reported muscle symptoms
Original publication
Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users. J Am Coll Cardiol. Published 11 April 2023. doi:10.
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