Heart failure & cardiomyopathies
Outcomes of left bundle branch area pacing upgrade in patients with right ventricular pacing-induced cardiomyopathy
Authors' conclusion
This study-the largest series investigating LBBAP for PICM to date-supports LBBAP as a viable, effective alternative to conventional cardiac resynchronization therapy in PICM, offering improvements in cardiac function and patient symptoms. However, larger randomized trials are needed to validate these findings in a broader, more heterogeneous population.
Study context
- Population
- Patients with pacemaker-induced cardiomyopathy (PICM) after right ventricular pacing who underwent left bundle branch area pacing (LBBAP)patients included
- Participants
- 64 patients
- Exposure
- Before vs after LBBAP
- LBBAPn = Sixty-four
- Outcome
- QRS duration
Main finding
As reported in the abstract
QRS duration before to after LBBAP
172.5 ± 21.9 to 133.4 ± 19.2 ms
P < .001
Observational data: associations, not effects.
Further findings
Left ventricular ejection fraction (LVEF)
- LVEF before LBBAP (mean)
- 36.5 ± 8.8
- Increase in LVEF (average)
- 11.0% ± 17.7% (P < .001)
New York Heart Association status
- NYHA status before to after LBBAP
- 2.72 ± 0.68 to 1.75 ± 0.6, P < .001
Lead extraction
- Lead extraction performed
- 18 of 64 patients (28%)
Outcomes by right ventricular pacing burden (≥90% vs <90%)
- Outcomes did not significantly differ
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →