Heart failure & cardiomyopathies
Efficacy on resynchronization and longitudinal contractile function comparing His-bundle pacing with conventional biventricular pacing: a substudy to the His-alternative study
Primary result · Mechanical dyssynchronyResult — go to the resultDifference −9.0 ms CI −36 to 18Authors' conclusion
In heart failure, patients with LBBB, BiV-CRT, and His-CRT have comparable effects with regard to improvements in mechanical dyssynchrony and longitudinal contractile function.
Study context
- Population
- Symptomatic HF, LVEF ≤ 35%, left bundle branch block (LBBB) by strict ECG criteriaon-treatment analysis
- Participants
- 19 vs 31
- Comparison
- His-CRT vs BiV-CRT
- His-CRTn = 19
- BiV-CRTn = 31reference
- Primary endpoint
- Change in mechanical dyssynchrony (SD of time-to-peak in 12 midventricular and basal segments) and regional longitudinal strain in the six LV walls
- Follow-up
- 6 months
Methodological detailson-treatment analysis
- On-treatment analysis
Primary result
Mechanical dyssynchrony
Difference
−9.0 ms
CI −36 to 18
P = 0.50
By group
His-CRTvs BiV-CRT
difference −9.0 ms (CI −36 to 18); P = 0.50
As reported in the abstract
Further findings
| Outcome | His-CRT | BiV-CRT | Difference (CI) | P value | |
|---|---|---|---|---|---|
| GLS · 6 monthsDifference in changes | −11.1% (SD 2.0) | −10.7% (SD 2.6) | −0.9% (−2.4 to −0.6) | P = 0.25 | |
| Baseline | −8.6% (±2.1) | −9.1% (±2.7) | |||
| Change P | P < 0.001 | P = 0.02 | |||
| −3−2−101Difference (linear scale) |
Original publication
Efficacy on resynchronization and longitudinal contractile function comparing His-bundle pacing with conventional biventricular pacing: a substudy to the His-alternative study. Eur Heart J Cardiovasc Imaging. Published 25 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →