Heart failure & cardiomyopathies
Early left bundle branch pacing in heart failure with mildly reduced ejection fraction and left bundle branch block
Authors' conclusion
Early LBBP with GDMT demonstrated greater improvement of cardiac function and reduced clinical events than GDMT alone in patients with HFmrEF and LBBB.
Study context
- Population
- Patients with HF with mildly reduced EF (HFmrEF) (LVEF 35%-50%) and left bundle branch blockenrolled and analysed
- Participants
- 54 patients
- Exposure
- Early left bundle branch pacing (LBBP) plus guideline-directed medical therapy (GDMT) vs GDMT alone
- Early-LBBPn = 37
- GDMTn = 15reference
- Outcome
- Changes in LVEF, LV end-diastolic diameter, NYHA class and NT-proBNP; clinical events (heart failure (HF) rehospitalization or syncope)
Methodological detailsconsecutive patients, prospectively enrolled
- Consecutive patients
- Prospectively enrolled
Main finding
As reported in the abstract
Change in LVEF · 6 months
- Early-LBBP vs GDMT: P < 0.001
Observational data: associations, not effects.
Further findings
Clinical events (HF rehospitalization or syncope) · 20.68 ± 13.55 months of follow-up
P < 0.001
- Change in LV end-diastolic diameter (LVEDD) · 6 months
- P < 0.001
- Change in New York Heart Association (NYHA) class · 6 months · greater reduction with LBBP: −0.84 ± 0.76 vs −0.13 ± 0.74
- P = 0.004
- Change in N-terminal pro-brain natriuretic peptide (NT-proBNP) · 6 months
- P = 0.610
- Change in LVEDD: greater reduction with LBBP: −7.51 ± 5.40 mm vs −0.87 ± 4.36 mm
- Change in NT-proBNP: similar reduction: −408.83 ± 920.29 pg/mL vs −229.05 ± 1579.17 pg/mL
LVEF improvement and LVEDD reduction, LBBB-Only vs LBBB-Combined (subgroup)
- LBBB-Only benefited more from LBBP than LBBB-Combined
Original publication
Early left bundle branch pacing in heart failure with mildly reduced ejection fraction and left bundle branch block. Heart Rhythm. Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →