Arrhythmias & electrophysiology
Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study
Authors' conclusion
Our study suggests that elevated Lp(a) (≥50 mg/dL) is an independent risk factor for incident AF.
Study context
- Population
- Adults with baseline Lp(a) and no atrial fibrillation (AF) history, 3 Mayo Clinic sitesmedian follow-up 8.8 years
- Participants
- 75,376 adults
- Exposure
- High Lp vs low Lp
- Outcome
- Incident AF
- Follow-up
- Up to 15 years
Methodological details3 Mayo Clinic sites
- 3 Mayo Clinic sites
Main finding
As reported in the abstract
Survival free from incident AF
P < 0.001
- Elevated Lp(a) and AF risk, multivariable-adjusted HR
- 1.11 (1.05-1.18) (95% CI)
Observational data: associations, not effects.
Original publication
Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study. Eur J Prev Cardiol. Published 7 February 2025. doi:10.
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