Arrhythmias & electrophysiology
The Burden of Cardiac Arrhythmias in Loeys-Dietz Syndrome: Prevalence, Etiology, and Therapeutic Interventions
Authors' conclusion
Cardiac arrhythmias occur frequently in LDS. Structural abnormalities like MVP and MAD are linked to ventricular arrhythmias.
Study context
- Population
- Patients with Loeys-Dietz syndrome (LDS) treated at Mayo Clinic sites
- Participants
- 94 patients
- Outcome
- Prevalence and clinical implications of cardiac arrhythmias, and complications of electrophysiological interventions
Methodological detailsMayo Clinic sites
- Mayo Clinic sites
Main finding
As reported in the abstract
Arrhythmia prevalence
- Atrial arrhythmias
- 31.9%
- AF
- 28.7%
- Atrial flutter
- 12.7%
- Supraventricular tachycardia
- 19.1%
- Ventricular arrhythmias (most unrelated to surgery)
- 20.2%
- Conduction abnormalities
- 37.2%
- Atrioventricular block (all third-degree after cardiac surgery)
- 31.9%
Observational data: associations, not effects.
Further findings
Association of mitral valve prolapse (MVP) and mitral annular disjunction (MAD) with ventricular arrhythmias
| OR (95% CI) | P value | ||
|---|---|---|---|
| MVPMVP prevalence 35.1% | 8.253 (2.623–25.961) | P < 0.001 | |
| MADMAD prevalence 11.7% | 10.354 (2.625–40.844) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Electrophysiological interventions
- Ablation
- 10.6%
- Pacemakers
- 7.5%
- ICD
- 2.2%
Safety
Complications of electrophysiological interventions
- High complication rate
Original publication
The Burden of Cardiac Arrhythmias in Loeys-Dietz Syndrome: Prevalence, Etiology, and Therapeutic Interventions. JACC Adv. Published 23 October 2025. doi:10.
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