Heart failure & cardiomyopathies
Emergent Role of Dynamic Optimization in Cardiac Resynchronization Therapy: Systematic Review and Network Meta-Analysis
Authors' conclusion
At the time of CRT implantation, dynamic algorithms may serve as a resource-friendly alternative to echocardiographic optimization, with similar or better mid-term outcomes.
Study context
- Population
- Patients with cardiac resynchronization therapy (CRT), including non-responders
- Participants
- 4,346 patients17 studies
- Comparison
- CRT optimization techniques: empirical settings vs echocardiography, static algorithms or dynamic algorithms
- Outcome
- Echocardiographic response, HF hospitalisation and 6-minute walk test improvement (dynamic algorithms vs echocardiography optimisation)
Pooled result
As reported in the abstract
Dynamic algorithms vs EchocardiographyOdds ratio (95% CrI)
Echocardiographic response rate
2.02(1.21–3.35)
HF hospitalisation rate
0.75(0.57–0.99)
Dynamic algorithms vs EchocardiographyMD, m (95% CrI)
6-minute walk test; CrI
45.52(3.91–82.44)
Further pooled results
- Initial non-responders improved after optimization, depending on response criteria
- 34.3%-66.7%
- 7 studies, 228 patients
Original publication
Emergent Role of Dynamic Optimization in Cardiac Resynchronization Therapy: Systematic Review and Network Meta-Analysis. ESC Heart Fail. Published 5 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →