Heart failure & cardiomyopathies
Atrioventricular optimization improves cardiac resynchronization response in patients with long interventricular electrical delays: A pooled analysis of the SMART-AV and SMART-CRT trials
Authors' conclusion
Greater CRT response and measures of reverse remodeling were observed in patients with SmartDelay enabled vs a fixed AV delay.
Study context
- Population
- Cardiac resynchronization therapy (CRT) patients with interventricular delay ≥70 mscomplete data sets pooled
- Participants
- 451 patients
- Comparison
- AVO algorithm vs fixed atrioventricular (AV) delay
- Outcome
- CRT response (≥15% reduction in LV end-systolic volume)
- Follow-up
- 6 months
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Pooled result
As reported in the abstract
CRT responders
P = 0.014
Further pooled results
| Outcome | Odds |
|---|---|
| CRT response, SmartDelay with recommended sensed AV delay outside nominal range (100-120 ms) (subgroup)2.3 greater odds of CRT response | 2.3 |
Reverse remodeling measures
- Greater changes in measures of reverse remodeling with AVO
Original publication
Atrioventricular optimization improves cardiac resynchronization response in patients with long interventricular electrical delays: A pooled analysis of the SMART-AV and SMART-CRT trials. Heart Rhythm. Published 9 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →