Heart failure & cardiomyopathiesCohort study
Endomyocardial Biopsy in the Diagnosis of Cardiac Sarcoidosis
- Retrospective cohort study
Authors' conclusion
The sensitivity of EMB in CS depends on the extent, activity, and location of myocardial involvement, being the higher the more severe CS is.
Study context
- Population
- Consecutive patients with cardiac sarcoidosis meeting Heart Rhythm Society diagnostic criteria (mean age 49 years, 60% female)216 (83%) underwent endomyocardial biopsy (EMB)
- Participants
- 260 patients
- Outcome
- Diagnostic sensitivity of endomyocardial biopsy (EMB) in cardiac sarcoidosis
Main finding
As reported in the abstract
EMB sensitivity
EMB overall sensitivity
38%
EMB sensitivity after repeat biopsies
49%
Observational data: associations, not effects.
Further findings
Independent predictors of positive EMB (logistic regression)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| presentation with ventricular tachyarrhythmia | 3.8 (1.2–12.0) | P = 0.021 | |
| left ventricular ejection fraction ≤45% | 3.7 (1.5–9.1) | P = 0.004 | |
| elevation of cardiac troponins | 2.7 (1.1–6.4) | P = 0.024 | |
| late gadolinium enhancement in left ventricular mid-apical septal segments on magnetic resonance imaging | 4.1 (1.2–13.8) | P = 0.024 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| EMB sensitivity (counting in repeats) by number of independent predictors | Without any independent predictor 16% · n = 37 · 1 predictor 38% · n = 76 · 2 predictors 60% · n = 62 · 3 predictors 79% · n = 33 · 4/4 predictors 88% · n = 8 |
Prognosis
- Positive EMB was not an independent predictor of prognosis
Safety
| Outcome | Values |
|---|---|
| Serious complications of EMB | EMB 0.7% |
Serious complications of EMB
- Without mortality or permanent harm
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Endomyocardial Biopsy in the Diagnosis of Cardiac Sarcoidosis. Eur J Heart Fail. Published 5 December 2024. doi:10.1002/ejhf.3545
Summarised from the published abstract; every number is checked against it