Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial
Primary result · VO2peak change (concurrent vs usual care during chemotherapy vs sequential vs usual care after chemotherapy)Result — go to the resultOverall difference −0.88 mL O2·kg-1·min-1 95% CI −3.36 to 1.59Authors' conclusion
There was no statistical difference in CRF improvement between concurrent vs. sequential exercise therapy relative to usual care in women with primary breast cancer.
Study context
- Population
- Inactive women with breast cancer initiating (neo)adjuvant chemotherapyn = 39/40 per group
- Participants
- 158 women
- Comparison
- Timing of exercise therapy vs usual care during and after chemotherapy
- Primary endpoint
- VO2peak change: concurrent exercise vs usual care during chemotherapy compared with sequential exercise vs usual care after chemotherapy
Methodological detailsparallel-group
- Parallel-group
Primary result
As reported in the abstract
VO2peak change (concurrent vs usual care during chemotherapy vs sequential vs usual care after chemotherapy)
Overall difference
−0.88 mL O2·kg-1·min-1
95% CI −3.36 to 1.59
P = 0.48
Concurrent vs Sequential
overall difference −0.88 mL O2·kg-1·min-1 (95% CI −3.36 to 1.59); P = 0.48
Further findings
- VO2peak change from baseline to post-intervention, continuous exercise
- 1.74 · mL O2·kg-1·min-1
- VO2peak change from baseline to post-intervention, continuous exercise — Continuous exercise the only strategy with significant VO2peak improvement
- P < 0.001
Original publication
Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial. Eur Heart J. Published 21 February 2023. doi:10.
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