Aortic & peripheral vascular diseaseRandomised controlled trial
Endovascular Therapy for Post-Thrombotic Syndrome — A Randomized Trial
- Randomised controlled trial
- blinded outcome assessment
Authors' conclusion
Among patients with moderate or severe post-thrombotic syndrome and iliac-vein obstruction, endovascular therapy led to less severe post-thrombotic syndrome and better health-related quality of life than standard care over a 6-month period but with a higher risk of bleeding.
Study context
- Population
- Moderate or severe post-thrombotic syndrome with imaging-confirmed iliac-vein obstruction
- Participants
- 225 participants
- Comparison
- Endovascular therapy plus standard care vs standard care alone
- Primary endpoint
- Severity of post-thrombotic syndrome by Venous Clinical Severity Score (VCSS) (0–30, higher = more severe)
- Follow-up
- 6 months
Primary result
VCSS
Adjusted difference
−2.0
P = 0.001
By group
Endovascular therapy
8.1
mean · SD 5.1
Standard care
10.0
mean · SD 4.9
As reported in the abstract
Secondary outcomes
| Outcome | adjusted difference (points) | P value |
|---|---|---|
| Venous disease-specific QoL (VEINES-QOL, 0–100) · 6 months | 14.5 | P < 0.001 |
| Overall QoL (SF-36 physical component summary, 0–100) · 6 months | 6.1 | P < 0.001 |
Safety
Bleeding · through 6 months
P = 0.03
Original publication
Endovascular Therapy for Post-Thrombotic Syndrome — A Randomized Trial. N Engl J Med. Published 13 April 2026. doi:10.1056/nejmoa2519001
Summarised from the published abstract; every number is checked against it