Aortic & peripheral vascular disease
Prevalence and patterns of in-stent neoatherosclerosis in lower extremity artery disease
Authors' conclusion
In-stent NA is frequently identified by OCT imaging after endovascular therapy in lower limb arteries; this increased both in frequency and extent the longer the duration since implantation.
Study context
- Population
- Symptomatic patients with lower extremity artery disease (LEAD) and in-stent restenosis (ISR) scheduled for endovascular intervention
- Participants
- 24 patients30 ISR lesions
- Outcome
- Prevalence and patterns of in-stent NA (≥1 fibroatheroma or fibrocalcific plaque within the neointima) by OCT
Methodological detailsintravascular optical coherence tomography (OCT)
- Intravascular OCT
Main finding
As reported in the abstract
In-stent NA prevalence
- Lesions with neoatherosclerosis (NA)
- 23 (76.7%)
- Stents implanted >5 years (n=8) with NA
- all
- Time from stent implantation to OCT significantly longer in lesions with NA
- p=0.002
Observational data: associations, not effects.
Further findings
Time from index procedure to OCT by extent of NA
- Shorter in lesions without NA than in those with ≥50% of frames with NA (n=9)
- P = 0.003
- Shorter in lesions without NA than in those with <50% of frames with NA (n=14)
- P = 0.015
Original publication
Prevalence and patterns of in-stent neoatherosclerosis in lower extremity artery disease. EuroIntervention. Published 24 April 2023. doi:10.
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