Endurance exercise promotes episodes of myocardial injury in individuals with a pathogenic desmoplakin (DSP) variant
Authors' conclusion
Endurance exercise may promote progression of DSP cardiomyopathy by increasing the risk of myocardial injury episodes, but the effect on VA and clinical HF is less clear.
Study context
- Population
- Adults with a pathogenic or likely pathogenic DSP variant
- Participants
- 100 adults
- Exposure
- Endurance athletes vs non-athletes
- Outcome
- Lifetime survival free of VA (VT/VF or appropriate ICD therapy), clinical HF (ED presentation or hospitalization with HF) and myocardial injury events
Main finding
As reported in the abstract
Endurance athletes vs Non-athletesHazard ratio (95% CI)
VA
1.00(0.5–1.98)
Clinical HF
0.86(0.36–2.05)
Myocardial injury
2.37(1.11–5.05)
Observational data: associations, not effects.
Further findings
VA and clinical heart failure (HF) after myocardial injury episodes
| HR (95% CI) | ||
|---|---|---|
| Myocardial injury episodesVA | 7.86 (3.56–17.33) | |
| Myocardial injury episodesClinical HF | 10.28 (2.95–35.83) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Endurance exercise promotes episodes of myocardial injury in individuals with a pathogenic desmoplakin (DSP) variant. Heart Rhythm. Published 30 December 2024. doi:10.
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