Arrhythmias & electrophysiology
Enhancement of bicycle exercise capacity in patients with chronotropic incompetence through closed-loop stimulation: a randomized crossover trial
Authors' conclusion
DDD-CLS mode pacing demonstrated improved exercise capacity and QoL in patients with CI, highlighting its potential as an effective pacing strategy for this patient population.
Study context
- Population
- Patients with chronotropic incompetence
- Participants
- 40 patients
- Comparison
- DDD-CLS vs DDD mode pacing
- Primary endpoint
- Exercise capacity by bicycle-based cardiopulmonary exercise testing (CPET)
- Follow-up
- 3- and 5-month visits
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Exercise capacity
| Group | Peak oxygen uptake | Oxygen uptake at ventilatory threshold |
|---|---|---|
| DDD-CLS | 14.8 ± 4.0 mL/kg/min | 10.0 ± 2.2 mL/kg/min |
| DDD | 12.0 ± 3.6 mL/kg/min | 8.7 ± 1.8 mL/kg/min |
Peak oxygen uptake
DDD-CLS14.8 ± 4.0 mL/kg/min
DDD12.0 ± 3.6 mL/kg/min
Oxygen uptake at ventilatory threshold
DDD-CLS10.0 ± 2.2 mL/kg/min
DDD8.7 ± 1.8 mL/kg/min
- DDD-CLS vs DDD: P < 0.001 — peak oxygen uptake
- DDD-CLS vs DDD: P < 0.001 — oxygen uptake at ventilatory threshold
Further findings
VE/VCO2 slope, oxygen uptake efficiency slope, end-tidal CO2
- No significant differences between the two modes
Health-related quality of life (QoL) and mode preference
- Preferred DDD-CLS mode
- 97.5%
- Better QoL with DDD-CLS
Original publication
Enhancement of bicycle exercise capacity in patients with chronotropic incompetence through closed-loop stimulation: a randomized crossover trial. Europace. Published 3 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →