Arrhythmias & electrophysiology
High prevalence and distinctive clinical features of LMNA-associated atrioventricular block in young patients
Authors' conclusion
LMNA variants are predominant in genotype positive patients and relevant to distinctive phenotypic properties.
Study context
- Population
- Patients aged <55 years with high-degree atrioventricular block (AVB) of unknown etiology
- Participants
- 41 patients
- Exposure
- LMNA variant carriers vs patients without LMNA variants
- LMNA variantsn = 11
- Outcome
- Genetic variants contributing to AVB of unknown reasons
Main finding
As reported in the abstract
Genetic variants identified
Genetic variants identified
20
20/41, 48.8%
LMNA variants among genotype-positive
11
11/20, 55%
LMNA variants: pathogenic / likely pathogenic / uncertain significance
3 / 4 / 3
Observational data: associations, not effects.
Further findings
Age at onset of AVB
P = 0.043
Family history of cardiac events
P < 0.000
Atrial arrhythmias
P < 0.000
Ventricular arrhythmias
P < 0.000
Left atrium size
P = 0.043
LV size
P = 0.036
Original publication
High prevalence and distinctive clinical features of LMNA-associated atrioventricular block in young patients. Am Heart J. Published 3 December 2023. doi:10.
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