Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Authors' conclusion
The utility of EAT as an imaging biomarker for predicting and prognosticating cardiovascular disease is promising, with increased EAT thickness and volume being identified as independent predictors of major adverse cardiovascular events.
Study context
- Population
- Adult patients with baseline epicardial adipose tissue (EAT) measurement and follow-up for CV outcomes29 articles
- Participants
- 19,709 patients
- Comparison
- Increased vs lower EAT by CT and echocardiography
- Outcome
- Major adverse cardiovascular events
Methodological detailsMedline and Embase searched without date restriction, May 2022; articles published 2012–2022
- Medline and Embase searched without date restriction, May 2022; articles published 2012–2022
Pooled result
As reported in the abstract
MACE per 1 unit increment in continuous EAT
Adjusted hazard ratio (95% CI)P value
CT volumetric quantification
1.74(1.42–2.13)
P < 0.001Echocardiographic thickness quantification
1.20(1.09–1.32)
P < 0.001Per 1 unit increment, as printed
Further pooled results
Cardiac death, MI, coronary revascularization, AF with increased EAT thickness and volume
| Estimate | P value | ||
|---|---|---|---|
| Increased EATCardiac death; n=4 studies | OR 2.53 (95% CI 1.17–5.44) | P = 0.020 | |
| Increased EATMI; n=5 studies | OR 2.63 (95% CI 1.39–4.96) | P = 0.003 | |
| Increased EATCoronary revascularization; n=5 studies | OR 2.99 (95% CI 1.64–5.44) | P < 0.001 | |
| Increased EATAF; n=3 studies | adjusted OR 4.04 (95% CI 3.06–5.32) | P < 0.001 | |
| 0.20.5125Ratio (log scale) |
Original publication
Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Circ Cardiovasc Imaging. Published 16 May 2023. doi:10.
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