Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease
Authors' conclusion
The simultaneous development of frailty and CI is associated with an increased risk of adverse cardiovascular outcomes including death compared with the development of each syndrome alone.
Study context
- Population
- Adults aged 65 and older without a history of CAD38.5% male
- Participants
- 2,189 adults
- Exposure
- Patterns of development of physical frailty and CI vs intact
- Frail-CIn = 195
- Frail firstn = 154
- CI firstn = 829
- Outcome
- Incident MACE
- Follow-up
- 5 years
Methodological detailsNational Health and Aging Trends Study linked to Medicare data
- National Health and Aging Trends Study linked to Medicare data
Main finding
As reported in the abstract
MACE
Each group vs intactHazard ratio (95% CI)
Frail-CI
1.81(1.47–2.23)
Frail first
1.46(1.17–1.81)
CI first
1.31(1.15–1.50)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| StrokeFrail firstvs Intact | 1.49 (1.06–2.09) | |
| 0.512Hazard ratio (log scale) |
Original publication
Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease. JACC Adv. Published 10 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →